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T15385 |
Glibornuride
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Potassium Channel
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Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent. |
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T9714 |
Atpenin A5
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Potassium Channel
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Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1]. |
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T1603 |
Glipizide
|
CP 28720,K 4024 |
Potassium Channel
,
PPAR
,
ABC
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Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
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T1634 |
Glibenclamide
|
Glyburide |
Potassium Channel
,
Mitochondrial Metabolism
,
CFTR
,
P-gp
,
Autophagy
|
|
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
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T1101 |
Minocycline hydrochloride
|
Minocycline HCl |
HIF/HIF Prolyl-Hydroxylase
,
Antibacterial
,
Antibiotic
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor... |
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T10566 |
BMS-191095
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Potassium Channel
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BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator. |
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T21478 |
Cromakalim
|
BRL-34915,BRL 34915,(±)-Cromakalim,BRL34915 |
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Cromakalim, a potassium channel-opening vasodilator, acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization, it can be used to treat hypertension as it will relax vascular smooth muscle to lowe... |
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T23563 |
ZM 226600
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|
Potassium Channel
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ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity. |
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T16420 |
P-1075
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Potassium Channel
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P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c... |
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T26086L |
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one
|
|
Others
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1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one is an isomer of Rilmakalim, a potassium channel opener (PCO), which can activate ATP-sensitive K+ channels in the heart or other tissues |
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T27624 |
Iptakalim Hydrochloride
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Potassium Channel
,
AChR
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Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... |
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T35107 |
Way 120491
|
Way120491,Way-120,491,Way-120491,Celikalim |
|
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Way 120491 activates ATP-sensitive potassium channels. |
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T71929 |
Clamikalant
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|
|
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Clamikalant inhibits ATP-sensitive potassium channel. |
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T70801 |
ZM-181037
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|
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ZM-181037 is an ATP-sensitive potassium channel-blocker and a eukalemic diuretic. |
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T11243 |
Ethyl tosylcarbamate
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Others
|
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Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). |
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T68745 |
U 56324
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|
|
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U-56324 is a hypoglycemic agent derived from nicotinic acid. It was found to inhibit the activity of ATP-sensitive potassium channels in excised patches from mouse pancreatic B-cells. |
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T68602 |
AZ-DF 265
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|
|
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AZ-DF 265 is a hypoglycaemic drug which stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels and displaces [3H]-glibenclamide from the sulphonylurea receptor. |
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T63330 |
Clamikalant sodium
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|
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Clamikalant sodium is a non-selective, ATP-sensitive potassium (KATP) channel blocker that can be used to study cardiac arrhythmias. |
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T75084 |
Foslevcromakalim
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|
|
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Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2]. |
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T25739 |
Linogliride
|
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
|
|
Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ... |
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T11002 |
Desethylamiodarone hydrochloride
|
N-desethylamiodarone hydrochloride,LB 33020 hydrochloride |
Others
|
|
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the... |
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T25739L |
Linogliride fumarate
|
McN 3935,McN-3935,McN3935 |
|
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Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassi... |
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T71402 |
Nicorandil-d4
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|
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir... |
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T71981 |
Gliclazide-d4
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Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ... |
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T36740 |
Guanosine 5’-diphosphate (sodium salt hydrate)
|
|
|
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Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR... |
